BACKGROUND: Knowledge in the aetiopathogeny of aortic disease helps to characterise
aortic lesions better and determine the risk of evolution and therapeutic strategies as well …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Extensive studies into the etiology of aortic aneurysm disease have focused on the
characteristic and unique inflammatory infiltration and elaboration of products of …

A disturbance of the structure of the aortic wall results in the formation of aortic aneurysm,
which is characterized by a significant bulge on the vessel surface that may have …

Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Smooth muscle cells and endothelial cells have a remarkable level of plasticity in vascular
pathologies. In thoracic and abdominal aortic aneurysms, smooth muscle cells have been …

Aortic aneurysms represent a very common pathology that can affect any segment of the
aorta. These types of aneurysms can be localized on the thoracic segment or on the …

The biology of aortic aneurysm and dissection has evolved to where we now understand the
genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and …

Thoracic aortic aneurysm develops as a result of complex series of events that alter the
cellular structure and the composition of the extracellular matrix of the aortic wall. The …

Aortic structure and function are controlled by the coordinated actions of different aortic cells
and the extracellular matrix. Several pathways have been identified that control the aortic …