Histone posttranslational modifications mediate establishment of structurally and functionally
distinct chromatin compartments of eukaryotic nuclei. The association of different histone …

Histone post‐translational modifications mark distinct structural and functional chromatin
states but little is known of their involvement in the progression of different cell cycle types …

Histone modifications are critical for the regulation of gene expression, cell type
specification, and differentiation. However, evolutionary patterns of key modifications that …

Histone modification is an important mechanism of gene regulation in eukaryotes. Why
many histone modifications can be stably maintained in the midst of genetic and …

A defining feature of heterochromatin is methylation of Lys9 of histone H3 (H3K9me), a
binding site for heterochromatin protein 1 (HP1). Although H3K9 methyltransferases and …

228 ILAR Journal discreet regions containing a preponderance of CpG content (Deaton and
Bird 2011). The resulting uneven distribution of CpG islands is thought to result from uniform …

Complex patterns of histone lysine methylation encode distinct functions within chromatin.
We previously reported that trimethylation of lysine 9 of histone H3 (H3K9) occurs at both …

Histone H3 lysine 9 (H3K9) methylation has broad roles in transcriptional repression, gene
silencing, maintenance of heterochromatin, and epigenetic inheritance of heterochromatin …

Histone modifications are central to the regulation of all DNA-dependent processes. Lys64
of histone H3 (H3K64) lies within the globular domain at a structurally important position. We …

Histone proteins contain epigenetic information that is encoded both in the relative
abundance of core histones and variants and particularly in the post-translational …