The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …

The relationship of exposure dose and tissue concentration of parent chemical and
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …

The metabolism of arsenic compounds in rats was studied by comparing urinary metabolites
of arsenic compounds administered for 1 wk or 7 mo. Male F344/DuCrj rats were given 100 …

Based on epidemiological data, chronic exposure to high levels of inorganic arsenic in
drinking water is carcinogenic to humans, inducing skin, urinary bladder and lung tumors. In …

Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the
disposition of arsenic after repeated exposure is not well known. This study examined the …

Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …

Abstract Arsenic (+ 3 oxidation state) methyltransferase (As3mt) catalyzes methylation of
inorganic arsenic (iAs) producing a number of methylated arsenic metabolites. Although …

Abstract Dose-Dependent Disposition of Sodium Arsenate in Mice Following Acute Oral
Exposure. Hughes, MF, Menache, M., and Thompson, DJ (1994). Fundam. Appl. Toxicol. 22 …

Adult female Fisher 344 rats received drinking water containing 0, 4, 40, 100, or 200 parts
per million of dimethylarsinic acid or 100 parts per million of arsenate for 14 days. Urine was …

This study presents a physiologically based pharmacokinetic model of inorganic arsenic
disposition in humans. The model focuses on short-term exposures by the oral route. The …