[HTML][HTML] Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against …

HE Jung, KB Ku, BH Kang, JH Park, HC Kim, KD Kim… - Antiviral Research, 2023 - Elsevier
The ongoing COVID-19 pandemic caused by SARS-CoV-2 infection has threatened global
health. Since the first case of infection was reported in December 2019, SARS-CoV-2 has …

[HTML][HTML] Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models

TL Freitag, R Fagerlund, NL Karam, VM Leppänen… - Vaccine, 2023 - Elsevier
The ongoing SARS-CoV-2 pandemic is controlled but not halted by public health measures
and mass vaccination strategies which have exclusively relied on intramuscular vaccines …

Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

NH Chung, YC Chen, SJ Yang, YC Lin, HY Dou… - Vaccine, 2022 - Elsevier
A series of recombinant human type 5 adenoviruses that express the full-length or
membrane-truncated spike protein (S) of SARS-CoV-2 (AdCoV2-S or AdCoV2-SdTM …

[PDF][PDF] Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge …

RG King, A Silva-Sanchez, JN Peel, D Botta… - DOI: https://doi. org …, 2021 - academia.edu
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for
effective prophylactic vaccination to prevent the spread of severe acute respiratory …

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

Adenoviral-vectored next-generation respiratory mucosal vaccines against COVID-19

S Afkhami, A Kang, V Jeyanathan, Z Xing… - Current Opinion in …, 2023 - Elsevier
The world is in need of next-generation COVID-19 vaccines. Although first-generation
injectable COVID-19 vaccines continue to be critical tools in controlling the current global …

Pre-clinical studies of a recombinant adenoviral mucosal vaccine to prevent SARS-CoV-2 infection

AC Moore, EG Dora, N Peinovich, KP Tucker, K Lin… - BioRxiv, 2020 - biorxiv.org
There is an urgent need to develop efficacious vaccines against SARS-CoV-2 that also
address the issues of deployment, equitable access, and vaccine acceptance. Ideally, the …

A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts

MD Schultz, JJ Suschak, D Botta… - Human Vaccines & …, 2022 - Taylor & Francis
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has illustrated the critical
need for effective prophylactic vaccination to prevent the spread of severe acute respiratory …

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge

RG King, A Silva-Sanchez, JN Peel, D Botta… - Vaccines, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for
effective prophylactic vaccination to prevent the spread of severe acute respiratory …

Intranasal liposomal formulation of spike protein adjuvanted with CpG protects and boosts heterologous immunity of hACE2 transgenic mice to SARS-CoV-2 infection

M Russo, MC Mendes-Corrêa, BB Lins, V Kersten… - Vaccines, 2023 - mdpi.com
Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this
study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a …