The Covid-19 pandemic highlighted the importance of quickly scaling up the production of
vaccines and other pharmaceutical products. These products are typically made within …

We report the findings of a detailed assessment of various options for computational two-
fluid RANS simulations of an aerated agitated 2-L bioreactor equipped with a single baffle …

Industrial bioprocessing is used to produce a variety of products, including pharmaceutical,
nutraceutical, chemicals, food, and other dairy products using microorganisms, animal cells …

Traditional design methods that rely on empirical correlations or physical experiments
frequently limit and lengthen design iterations. Computational fluid dynamics (CFD) …

This book covers emerging areas in novel design and their hydrodynamic properties
relevant to bioreactors, environmental system, electrochemical systems, food processing …

During a cell culture in a bioreactor, the cells are exposed to the shear stresses mainly
generated in the culture medium by the mixing device. Beyond a critical shear stress, this …

Aerobic bioreactors are widely used in the synthesis of value-added products in
pharmaceutical and biotechnology industries, wherein microbial bioreactions aid in the …

Mixing in bioreactors is known to be crucial for achieving efficient mass and heat transfer,
both of which thereby impact not only growth of cells but also product quality. In a typical …

Mixing is a critical phenomenon in bioreactors and its importance increases with the size of
the reactor. For proper microbial growth, it is desirable to have uniform distribution of …

Two-way Euler-Lagrange simulations are performed to characterize the hydrodynamics in
the single-use bioreactor Mobius® CellReady 3 L. The hydrodynamics in stirred tank …