Here we report a new isolation method for mouse glomeruli. The method is fast and simple
and allows for the isolation of virtually all glomeruli present in the adult mouse kidney with …

To advance our understanding of development, function and diseases in the kidney
glomerulus, we have established and large‐scale sequenced cDNA libraries from mouse …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …

The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure
kidney functions, the nephrons possess a highly segmental organization where each …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

The kidney is a highly specialized organ with a complex, stereotyped architecture and a
great diversity of functions and cell types. Because the microscopic organization of the …

To gain a molecular understanding of kidney functions, we established a high-resolution
map of gene expression patterns in the human kidney. The glomerulus and seven different …

Since the development of methods for homologous gene recombination, mouse models
have played a central role in research in renal pathophysiology. However, many published …

The nephron is the functional unit of the kidney, but the mechanism of nephron formation
during human development is unclear. We conducted a detailed analysis of nephron …

The functional unit of the kidney is the nephron. During its organogenesis, the mammalian
metanephric kidney generates thousands of nephrons over a protracted period of fetal life …