Protein expression profiles linked to sclerosis in the 5/6 nephrectomy (Nx) rat model of focal
segmental glomerulosclerosis were investigated. Sections of control glomeruli from normal …

The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

Background The pronephros, the simplest form of a vertebrate excretory organ, has recently
become an important model of vertebrate kidney organogenesis. Here, we elucidated the …

Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms
underlying these roles are not well understood. Here, we performed a single-cell RNA …

The function of each renal tubule segment depends on the genes expressed therein. High-
throughput methods used for global profiling of gene expression in unique cell types have …

Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in
models of kidney development. Background In a recent study, the pattern of gene …

The assignment of cell type names to individual cell clusters in single-cell RNA-sequencing
(RNA-seq; including single-nucleus RNA-seq) studies is a critical bioinformatic step …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Differential expression of proteins in renal cortex and medulla: A proteomic approach.
Background Western blotting has previously been used to identify changes in protein …