The blood-brain barrier (BBB) is responsible for maintaining homeostasis of the brain by
regulating the chemical environment, immune cell transport, and the entry of toxins and …

The blood-brain barrier (BBB) remains a major roadblock to the delivery of drugs to the
brain. While in vitro and in vivo measurements of permeability are widely used to predict …

The multidrug transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier
endothelium where it effluxes a range of drug substrates, preventing their accumulation …

Drug resistance to chemotherapeutic drugs is a very challenging problem that often results
in clinical failure of highly effective medications. A major mechanism of drug resistance can …

We report molecular dynamics simulations of rhodamine entry into the central binding cavity
of P-gp in the inward open conformation. Rhodamine can enter the inner volume via passive …

The broad range of substrates that can be transported by the transmembrane protein, P‐
glycoprotein (P‐gp), has been well established. While best known for the ability to confer …

Active efflux transport processes at the blood–brain barrier (BBB), such as P-glycoprotein (P-
gp)-mediated efflux, can limit brain uptake of therapeutics. Accurate determination of the …

The blood-brain barrier is formed by endothelial cells of brain capillaries. It protects the
central nervous system from xenobiotics, dangerous metabolites, and toxins. This chapter …

P-glycoprotein (P-gp) exports a broad range of dissimilar compounds, including drugs,
lipids, and lipid-like molecules. Because of its substrate promiscuity, P-gp is a key player in …

The central nervous system (CNS) effects of many therapeutic drugs are blunted because of
restricted entry into the brain. The basis for this poor permeability is the brain capillary …