The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

The current pathogenic scenarios of different types of dementia are based on a number of
common mechanisms of neurodegeneration, such as accumulation of abnormal proteins …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Life expectancy has increased in most developed countries, which has led to an increase in
the proportion of elderly people in the world's population. However, this increase in life …

The age-associated decline of the neurological and cognitive functions becomes more and
more serious challenge for the developed countries with the increasing number of aged …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

During the last decade, several articles have reported a relationship between advanced age
and changes in the integrity of the blood-brain barrier (BBB). These changes were …

Abstract Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder
characterized by senile plaques and neurofibrillary tangles, is the most common form of …

Aging is commonly associated with progressive deterioration in central nervous system
(CNS) function. Nutritional factors or environmental toxins have important effects on CNS …