The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

Aging involves a decline in neural function that contributes to cognitive impairment and
disease. However, the mechanisms underlying the transition from a young-and-healthy to …

Aims While vascular pathology is a common feature of a range of neurodegenerative
diseases, we hypothesized that vascular changes occur in association with normal ageing …

The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …

Neurodegenerative disorders represent a major medical challenge that is set to increase
substantially in the decades ahead with the massive increase in the number of people in the …

In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the
pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles …

The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …

The integrity of the cerebral vasculature is crucial to the maintenance of cognitive functions
during ageing. Prevailing evidence suggests that cerebrovascular functions decline during …