With age, our cognitive skills and abilities decline. Maybe starting as an annoyance, this
decline can become a major impediment to normal daily life. Recent research shows that the …

Aging of the cerebral microcirculation results in significant alteration in the blood-brain
barrier (BBB). The barrier function appears to remain intact in older animals, although it may …

As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of …

The blood–brain barrier (BBB) represents the interface between the brain and other body
tissues. Its ability to protect the brain from harmful compounds has attracted the attention of …

Neurological degeneration after neuroinflammation, such as that resulting from Alzheimer's
disease (AD), stroke, multiple sclerosis (MS), and post-traumatic brain injury (TBI), is …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Background Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to
pathogenesis and pathology of vascular-based neurodegenerative disorders such as …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …