Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis

X Zhao, Q Kan, L Zhu, GX Zhang - The American journal of Chinese …, 2011 - World Scientific
Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has
been suggested to possess immunomodulatory characteristics; however, whether it is …
被引用次数：39 相关文章 所有 4 个版本
[PDF] frontiersin.org

Matrine inhibits CNS autoimmunity through an IFN-β-dependent mechanism

YJ Chu, WD Ma, R Thome, JD Ping, FZ Liu… - Frontiers in …, 2020 - frontiersin.org
Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora
flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal …
被引用次数：23 相关文章 所有 8 个版本

Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis

N Liu, Q Kan, X Zhang, Y Xv, S Zhang… - … and molecular pathology, 2014 - Elsevier
Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a …
被引用次数：59 相关文章 所有 5 个版本

Matrine promotes oligodendrocyte development in CNS autoimmunity through the PI3K/Akt signaling pathway

SQ Liu, ML Zhang, HUJ Zhang, FZ Liu, RJ Chu… - Life sciences, 2017 - Elsevier
Aims Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae
flavescens, has been recently found to be beneficial in experimental autoimmune …
被引用次数：41 相关文章 所有 4 个版本

Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity

QC Kan, L Zhu, N Liu, GX Zhang - Immunologic research, 2013 - Springer
Experimental autoimmune encephalomyelitis (EAE) is a classical experimental model of
multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) …
被引用次数：50 相关文章 所有 8 个版本

Matrine ameliorates experimental autoimmune encephalomyelitis by modulating chemokines and their receptors

QC Kan, Q Pan, XJ Zhang, Y Chu, N Liu, P Lv… - Experimental and …, 2015 - Elsevier
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune diseases characterized by immune-mediated neuroinflammation …
被引用次数：17 相关文章 所有 4 个版本

Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis

X Zhao, X Zhang, Y Lv, Y Xu, M Li, Q Pan, Y Chu… - Immunology …, 2016 - Elsevier
Abstract Interleukin (IL)-33 is a recently described member of the IL-1 family and functions as
a ligand for ST2, a member of the IL-1 receptor family. The role of IL-33/ST2 axis in the …
被引用次数：12 相关文章 所有 5 个版本

Matrine protects neuro-axon from CNS inflammation-induced injury

QC Kan, P Lv, XJ Zhang, YM Xu, GX Zhang… - … and Molecular Pathology, 2015 - Elsevier
Neuro-axonal injury in the central nervous system (CNS) is one of the major pathological
hallmarks of experimental autoimmune encephalomyelitis (EAE), an experimental model of …
被引用次数：31 相关文章 所有 5 个版本

Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling

L Zhu, Q Pan, XJ Zhang, YM Xu, Y Chu, N Liu… - Experimental and …, 2016 - Elsevier
Abstract Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal
degeneration are primary characteristics of multiple sclerosis (MS) and its animal model …
被引用次数：32 相关文章 所有 4 个版本

Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis

ML Zhang, XJ Zhang, J Kang, HJ Zhang, XL Chen… - Neuroscience …, 2017 - Elsevier
Abstract Neurotrophin 3 (NT3) is a potent neurotrophic factor for promoting remyelination
and recovery of neuronal function; upregulation of its expression in the central nervous …
被引用次数：27 相关文章 所有 5 个版本