Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity
QC Kan, L Zhu, N Liu, GX Zhang - Immunologic research, 2013 - Springer
Experimental autoimmune encephalomyelitis (EAE) is a classical experimental model of
multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) …
multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS) …
Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis
N Liu, Q Kan, X Zhang, Y Xv, S Zhang… - … and molecular pathology, 2014 - Elsevier
Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its
animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a …
animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a …
[HTML][HTML] Matrine inhibits CNS autoimmunity through an IFN-β-dependent mechanism
Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora
flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal …
flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal …
Matrine protects neuro-axon from CNS inflammation-induced injury
QC Kan, P Lv, XJ Zhang, YM Xu, GX Zhang… - … and Molecular Pathology, 2015 - Elsevier
Neuro-axonal injury in the central nervous system (CNS) is one of the major pathological
hallmarks of experimental autoimmune encephalomyelitis (EAE), an experimental model of …
hallmarks of experimental autoimmune encephalomyelitis (EAE), an experimental model of …
Matrine ameliorates experimental autoimmune encephalomyelitis by modulating chemokines and their receptors
QC Kan, Q Pan, XJ Zhang, Y Chu, N Liu, P Lv… - Experimental and …, 2015 - Elsevier
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis
(EAE), are autoimmune diseases characterized by immune-mediated neuroinflammation …
(EAE), are autoimmune diseases characterized by immune-mediated neuroinflammation …
Inhibitory Effect of Matrine on Blood‐Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis
S Zhang, QC Kan, Y Xu, GX Zhang… - Mediators of …, 2013 - Wiley Online Library
Dysfunction of the blood‐brain barrier (BBB) is a primary characteristic of experimental
autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS) …
autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS) …
Matrine promotes oligodendrocyte development in CNS autoimmunity through the PI3K/Akt signaling pathway
SQ Liu, ML Zhang, HUJ Zhang, FZ Liu, RJ Chu… - Life sciences, 2017 - Elsevier
Aims Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae
flavescens, has been recently found to be beneficial in experimental autoimmune …
flavescens, has been recently found to be beneficial in experimental autoimmune …
Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis
X Zhao, Q Kan, L Zhu, GX Zhang - The American journal of Chinese …, 2011 - World Scientific
Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has
been suggested to possess immunomodulatory characteristics; however, whether it is …
been suggested to possess immunomodulatory characteristics; however, whether it is …
Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling
L Zhu, Q Pan, XJ Zhang, YM Xu, Y Chu, N Liu… - Experimental and …, 2016 - Elsevier
Abstract Inflammation, demyelination, oligodendrocyte (OLG) death, and axonal
degeneration are primary characteristics of multiple sclerosis (MS) and its animal model …
degeneration are primary characteristics of multiple sclerosis (MS) and its animal model …
[HTML][HTML] Illumination of molecular pathways in multiple sclerosis lesions and the immune mechanism of matrine treatment in EAE, a mouse model of MS
M Dou, X Zhou, L Li, M Zhang, W Wang… - Frontiers in …, 2021 - frontiersin.org
The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great
challenge. This study aimed to investigate the pathogenesis and potential therapeutic …
challenge. This study aimed to investigate the pathogenesis and potential therapeutic …