Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

SJ Zost, P Gilchuk, JB Case, E Binshtein, RE Chen… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
Mutations and transient conformational movements of the receptor binding domain (RBD)
that make neutralizing epitopes momentarily unavailable present immune escape routes for …

Competitive SARS-CoV-2 serology reveals most antibodies targeting the spike receptor-binding domain compete for ACE2 binding

JR Byrnes, XX Zhou, I Lui, SK Elledge, JE Glasgow… - MSphere, 2020 - Am Soc Microbiol
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
around the world, there is an urgent need for new assay formats to characterize the humoral …

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

AL Cathcart, C Havenar-Daughton, FA Lempp, D Ma… - biorxiv, 2021 - biorxiv.org
ABSTRACT VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs)
targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Targeting SARS-CoV2 spike protein receptor binding domain by therapeutic antibodies

A Hussain, A Hasan, MMN Babadaei, SH Bloukh… - Biomedicine & …, 2020 - Elsevier
As the number of people infected with the newly identified 2019 novel coronavirus (SARS-
CoV2) is continuously increasing every day, development of potential therapeutic platforms …

[HTML][HTML] RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

Z Liu, W Xu, S Xia, C Gu, X Wang, Q Wang… - Signal transduction and …, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has posed serious threats to global health and …

[HTML][HTML] A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

R Shi, C Shan, X Duan, Z Chen, P Liu, J Song, T Song… - Nature, 2020 - nature.com
An outbreak of coronavirus disease 2019 (COVID-19),–, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spread globally. Countermeasures are needed …

The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement

BD Quinlan, H Mou, L Zhang, Y Guo, W He, A Ojha… - Biorxiv, 2020 - biorxiv.org
SUMMARY The SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates entry of
SARS-CoV-2 into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S …

Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy

X Zeng, L Li, J Lin, X Li, B Liu, Y Kong… - Antibody …, 2020 - academic.oup.com
The infection of the novel coronavirus severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused more than 200 000 deaths, but no vaccine or therapeutic …

[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
The worldwide spread of COVID-19 highlights the need for an efficient approach to rapidly
develop therapeutics and prophylactics against SARS-CoV-2. The SARS-CoV-2 spike …