[HTML][HTML] SARS-CoV-2 spike protein: flexibility as a new target for fighting infection
CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …
crucial for the infection because it mediates the virus entry into human host-cells, through …
[HTML][HTML] Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
D Mannar, JW Saville, X Zhu, SS Srivastava… - Cell Reports, 2021 - cell.com
The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Beta
(B. 1.351) and Gamma (P. 1) variants of concern (VoCs) include a key mutation (N501Y) …
(B. 1.351) and Gamma (P. 1) variants of concern (VoCs) include a key mutation (N501Y) …
Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11
The emergence of SARS-CoV-2 antibody escape mutations highlights the urgent need for
broadly neutralizing therapeutics. We previously identified a human monoclonal antibody …
broadly neutralizing therapeutics. We previously identified a human monoclonal antibody …
[HTML][HTML] Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects
MF Jennewein, AJ MacCamy, NR Akins, J Feng… - Cell reports, 2021 - cell.com
SARS-CoV-2 is one of three coronaviruses that have crossed the animal-to-human barrier
and caused widespread disease in the past two decades. The development of a universal …
and caused widespread disease in the past two decades. The development of a universal …
[HTML][HTML] An infectious SARS-CoV-2 B. 1.1. 529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies
The emergence of the highly transmissible B. 1.1. 529 Omicron variant of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody …
[HTML][HTML] SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health
crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain …
crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain …
[HTML][HTML] Evidence of escape of SARS-CoV-2 variant B. 1.351 from natural and vaccine-induced sera
The race to produce vaccines against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …
(SARS-CoV-2) began when the first sequence was published, and this forms the basis for …
Safety, virologic efficacy, and pharmacokinetics of CT-P59, a neutralizing monoclonal antibody against SARS-CoV-2 spike receptor-binding protein: two randomized …
JY Kim, YR Jang, JH Hong, JG Jung, JH Park… - Clinical Therapeutics, 2021 - Elsevier
Purpose Neutralizing antibodies can reduce SARS-CoV-2 cellular entry, viral titers, and
pathologic damage. CT-P59 (regdanvimab), a SARS-CoV-2 neutralizing monoclonal …
pathologic damage. CT-P59 (regdanvimab), a SARS-CoV-2 neutralizing monoclonal …
[HTML][HTML] Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …
mediated immunity. To facilitate prospective surveillance for such evolution, we map how …
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
Y Wu, F Wang, C Shen, W Peng, D Li, C Zhao, Z Li, S Li… - Science, 2020 - science.org
Neutralizing antibodies could potentially be used as antivirals against the coronavirus
disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin …
disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin …