Cytokine storm and colchicine potential role in fighting SARS-CoV-2 pneumonia

A Vitiello, F Ferrara, C Pelliccia, G Granata… - Italian Journal of …, 2020 - italjmed.org
For some patients with SARS-CoV-2, the worst clinical damage is not caused by the virus
itself, but by an overactive inflammatory state. In fact, in some people the immune system …

[HTML][HTML] Colchicine and SARS-CoV-2: management of the hyperinflammatory state

A Vitiello, F Ferrara - Respiratory Medicine, 2021 - Elsevier
The global COVID-19 pandemic is currently underway. In December 2020, the European
Agency of Medicine (EMA) licensed the first Sars-CoV-2 vaccine. Therapeutic management …

Why not to use colchicine in COVID-19? An oldanti-inflammatory drug for a novel auto-inflammatory disease

S Piantoni, A Patroni, P Toniati, R Furloni… - …, 2020 - academic.oup.com
DEAR EDITOR, Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)
infection disease (COVID-19) is a novel disease identified in a cluster of pneumonia in the …

Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute …

M Scarsi, S Piantoni, E Colombo, P Airó… - Annals of the …, 2020 - ard.bmj.com
Objectives The outbreak of COVID-19 posed the issue of urgently identifying treatment
strategies. Colchicine was considered for this purpose based on well-recognised anti …

Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial

MIF Lopes, LP Bonjorno, MC Giannini, NB Amaral… - MedRxiv, 2020 - medrxiv.org
Introduction Neutrophilia and high levels of proinflammatory cytokines and other mediators
of inflammation are common finds in patients with severe acute respiratory syndrome due to …

Tocilizumab in SARS-CoV-2 patients with the syndrome of cytokine storm: A narrative review

S Kulanthaivel, VB Kaliberdenko… - Reviews on Recent …, 2021 - ingentaconnect.com
Introduction: Corona virus is a group of viruses that cause diseases in mammals and birds.
In humans, these families of viruses can cause respiratory infections from a mild form to fatal …

Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study

V Mareev, Y Orlova, A Plisyk, E Pavlikova, Z Akopyan… - 2021 - covid19.neicon.ru
Actuality The course of the novel coronavirus disease (COVID-19) is unpredictable. In some
cases, it manifests as increasing inflammation that leads to a cytokine storm and irreversible …

Colchicine against SARS-CoV-2 infection: what is the evidence?

AA Drosos, E Pelechas, V Drossou… - Rheumatology and …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a matter of concern worldwide and a huge …

Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID‐19 pneumonia patients

B Borku Uysal, H Ikitimur, S Yavuzer… - Journal of medical …, 2020 - Wiley Online Library
To recognize the period of exaggerated cytokine response in patients with coronavirus
disease 2019 (COVID‐19) pneumonia, and to describe the clinical outcomes of using …

Effect of increasing doses of colchicine on the treatment of 333 COVID‐19 inpatients

R Tiholov, AI Lilov, G Georgieva… - Immunity …, 2024 - Wiley Online Library
Background Previous research done in Bulgaria demonstrated a fivefold reduction in
mortality from COVID‐19 with increased doses of colchicine from two hospitals in the …