The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: major contributors or essential homeostatic modulators?

DJ Ahern, FM Brennan - Immunology letters, 2011 - Elsevier
Natural Killer (NK) cells are lymphocytes of the innate immune system, originally described
by their capacity to control tumour cells and eliminate virus-infected cells. However …

Natural killer cells and their role in rheumatoid arthritis: friend or foe?

H Shegarfi, F Naddafi… - The Scientific World …, 2012 - Wiley Online Library
Rheumatoid arthritis (RA) is a long‐term disease that leads to inflammation of the joints and
surrounding tissues. Natural killer (NK) cells are an important part of the innate immune …

Natural killer cells in human autoimmune disorders

LA Fogel, WM Yokoyama, AR French - Arthritis research & therapy, 2013 - Springer
Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense
against viruses. Through their cytolytic capacity and generation of cytokines and …

Natural killer cells and autoimmunity

AR French, WM Yokoyama - Arthritis Res Ther, 2003 - Springer
Autoimmune diseases are often characterized as clinical syndromes caused by the
inappropriate activation of T or B cells resulting in systemic or organ-specific damage …

Mobilization of natural killer cells inhibits development of collagen-induced arthritis

JW Leavenworth, X Wang… - Proceedings of the …, 2011 - National Acad Sciences
Although natural killer (NK) cells have been implicated in regulating immune responses,
their ability to modulate disease development in autoimmune arthritis has not been …

NKT cells: manipulable managers of joint inflammation

K Coppieters, P Dewint, K Van Beneden… - …, 2007 - academic.oup.com
The importance of T cell participation in the aetiology and pathogenesis of rheumatoid
arthritis (RA) is now widely appreciated. The disease is mediated by activated pro …

Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion

CT De Matos, L Berg, J Michaëlsson… - …, 2007 - Wiley Online Library
Natural killer (NK) cells are activated early during inflammatory events and contribute to the
shaping of the ensuing adaptive immune response. To further understand the role for NK …

Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype

C Pridgeon, GP Lennon, L Pazmany… - …, 2003 - academic.oup.com
Background. Natural killer (NK) cells play an important role in several animal models of
autoimmunity by modulating T‐cell responses, but it is unclear whether human NK cells …

The role of NK cells in rheumatoid arthritis

A Fathollahi, LN Samimi, M Akhlaghi, A Jamshidi… - Inflammation …, 2021 - Springer
Objective Natural killer (NK) cells are part of the innate immune system which not only
provides a primary response to pathogenic conditions but can also play an important …

Natural killer cells in inflammatory autoimmune diseases

Y Yang, J Day… - Clinical & …, 2021 - Wiley Online Library
Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help
control local immune responses. Through natural cytotoxicity, production of cytokines and …