In recent years, it has become increasingly clear that mitochondrial dysfunction and
oxidative damage are major contributors to neuronal loss. Free radicals, typically generated …

Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
progressive development of involuntary choreiform movements, cognitive impairment …

Huntington's disease (HD) is a neurodegenerative disorder with an autosomal dominant
expression pattern and typically a late-onset appearance. HD is a movement disorder with a …

Huntington's disease (HD) is the most common polyglutamine neurodegenerative disorder
in humans, and is caused by a mutation of an unstable expansion of CAG repeats within the …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia (FRDA), multiple …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
characterized by progressive motor dysfunction, emotional disturbances, dementia, and …

Many forms of neurodegeneration are associated with oxidative stress and mitochondrial
dysfunction. Mitochondria are prominent targets of oxidative damage, however, it is not clear …

Oxidative stress and mitochondrial dysfunction have been implicated in the pathology of HD;
however, the precise mechanisms by which mutant huntingtin modulates levels of oxidative …

Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases
leading to the generation of lipid peroxides, carbonyl proteins and oxidative DNA damage in …