SARS-CoV-2 is a human pathogen that causes infection in both the upper respiratory tract
(URT) and the lower respiratory tract (LRT). The viral kinetics of SARS-CoV-2 infection and …

The within-host viral kinetics of SARS-CoV-2 infection and how they relate to a person's
infectiousness are not well understood. This limits our ability to quantify the impact of …

Relationships between viral load, severity of illness, and transmissibility of virus are
fundamental to understanding pathogenesis and devising better therapeutic and prevention …

SUMMARY the best methods for controlling its spread, and data on public health
preventative measures continue to emerge. In this paper we review the available evidence …

Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a
mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques …

The scientific community is focussed on developing antiviral therapies to mitigate the
impacts of the ongoing novel coronavirus disease (COVID-19) outbreak. This will be …

The impact of a prior SARS-CoV-2 infection on the progression of subsequent infections has
been unclear. Using a convenience sample of 94,812 longitudinal RT-qPCR measurements …

Health outcomes following infection with Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) are remarkably variable. The way the virus spreads inside hosts, and how …

The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly
understood. We captured the dynamics of infectious virus and viral RNA shedding during …

The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …