Baricitinib plus remdesivir for hospitalized adults with Covid-19
Abstract Background Severe coronavirus disease 2019 (Covid-19) is associated with
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus …
An updated overview of recent advances, challenges, and clinical considerations of IL-6 signaling blockade in severe coronavirus disease 2019 (COVID-19)
R Elahi, P Karami, AH Heidary… - International …, 2022 - Elsevier
Abstract Since 2019, COVID-19 has become the most important health dilemma around the
world. The dysregulated immune response which results in ARDS and cytokine storm has …
world. The dysregulated immune response which results in ARDS and cytokine storm has …
A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine–related JAK-STAT signal
C Chen, Y Yin, G Shi, Y Zhou, S Shao, Y Wei, L Wu… - Science …, 2022 - science.org
Janus kinases (JAKs) play a critical role in immune responses by relaying signals from more
than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases …
than 50 cytokines, making them attractive therapeutic targets for autoimmune diseases …
Imatinib a Tyrosine Kinase Inhibitor: a potential treatment for SARS-COV-2 induced pneumonia
HS Assaad, S Assaad-Khalil - Alexandria Journal of Medicine, 2020 - ajol.info
Introduction: As the coronavirus disease (COVID-19) spreads worldwide, awaiting the
development of a vaccine, researchers are looking among the arsenal of available drugs, for …
development of a vaccine, researchers are looking among the arsenal of available drugs, for …
The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
MS Basile, E Cavalli, J McCubrey… - Drug discovery today, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has emerged as a serious threat to global
health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian …
health. The disregulation of the phosphatidylinositol 3-kinase/protein kinase B/mammalian …
Priority index for critical Covid-19 identifies clinically actionable targets and drugs
While genome-wide studies have identified genomic loci in hosts associated with life-
threatening Covid-19 (critical Covid-19), the challenge of resolving these loci hinders further …
threatening Covid-19 (critical Covid-19), the challenge of resolving these loci hinders further …
[HTML][HTML] Calming the inflammatory storm in severe COVID-19 infections: Role of biologics-A narrative review
The risk of Coronavirus infection continues, and the fear of resurgence indicates the lack of a
successful therapeutic strategy. In severe COVID-19 infection, many immune cells and their …
successful therapeutic strategy. In severe COVID-19 infection, many immune cells and their …
Janus kinase inhibitors and cell therapy
A Assal, MY Mapara - Frontiers in Immunology, 2021 - frontiersin.org
Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and
immune-effector cell therapy (IECT) continue to have a critical role in the treatment of …
immune-effector cell therapy (IECT) continue to have a critical role in the treatment of …
Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes
Summary SARS-CoV-2-infected subjects are generally asymptomatic during initial viral
replication but may suffer severe immunopathology after the virus has receded and …
replication but may suffer severe immunopathology after the virus has receded and …
Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm
COVID-19-infected patients require an intact immune system to suppress viral replication
and prevent complications. However, the complications of SARS-CoV-2 infection that led to …
and prevent complications. However, the complications of SARS-CoV-2 infection that led to …