Stimuli-responsive codelivery of oligonucleotides and drugs by self-assembled peptide nanoparticles

SJ Sigg, V Postupalenko, JT Duskey… - …, 2016 - ACS Publications
Ever more emerging combined treatments exploiting synergistic effects of drug combinations
demand smart, responsive codelivery carriers to reveal their full potential. In this study, a …

Slow release and delivery of antisense oligonucleotide drug by self-assembled peptide amphiphile nanofibers

S Bulut, TS Erkal, S Toksoz, AB Tekinay… - …, 2011 - ACS Publications
Antisense oligonucleotides provide a promising therapeutic approach for several disorders
including cancer. Chemical stability, controlled release, and intracellular delivery are crucial …

[HTML][HTML] Doxorubicin-triggered self-assembly of native amphiphilic peptides into spherical nanoparticles

X Fan, F Zhao, X Wang, G Wu - Oncotarget, 2016 - ncbi.nlm.nih.gov
In this study, we designed and fabricated self-assembly nanospheres, which consisted of a
P45 peptide and doxorubicin (Dox). P45 is a hybrid peptide composed of an Arg-Gly-Asp …

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

HS Buddhiraju, DN Yadav, S Dey, K Eswar… - ACS Applied Bio …, 2023 - ACS Publications
Peptides are ideal biologicals for targeted drug delivery and have also been increasingly
employed as theranostic tools in treating various diseases, including cancer, with minimal or …

A self-assembling amphiphilic peptide nanoparticle for the efficient entrapment of DNA cargoes up to 100 nucleotides in length

S Tarvirdipour, CA Schoenenberger, Y Benenson… - Soft Matter, 2020 - pubs.rsc.org
To overcome the low efficiency and cytotoxicity associated with most non-viral DNA delivery
systems we developed a purely peptidic self-assembling system that is able to entrap single …

Enzyme-responsive amphiphilic peptide nanoparticles for biocompatible and efficient drug delivery

SJ Song, JS Choi - Pharmaceutics, 2022 - mdpi.com
Self-assembled peptide nanostructures recently have gained much attention as drug
delivery systems. As biomolecules, peptides have enhanced biocompatibility and …

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

N Habibi, N Kamaly, A Memic, H Shafiee - Nano today, 2016 - Elsevier
Self-assembly of peptides can yield an array of well-defined nanostructures that are highly
attractive nanomaterials for many biomedical applications such as drug delivery. Some of …

Molecularly stimuli-responsive self-assembled peptide nanoparticles for targeted imaging and therapy

Y Zhou, Q Li, Y Wu, X Li, Y Zhou, Z Wang, H Liang… - ACS …, 2023 - ACS Publications
Self-assembly has emerged as an extensively used method for constructing biomaterials
with sizes ranging from nanometers to micrometers. Peptides have been extensively …

Delivery of therapeutics and molecules using self-assembled peptides

S Sundar, Y Chen, YW Tong - Current medicinal chemistry, 2014 - ingentaconnect.com
The use of nanobiotechnology in the formulation of drug carriers has been gaining
popularity in recent years. Peptide self-assembly technology is a particularly attractive option …

Nucleic acid nanocapsules for enzyme-triggered drug release

JK Awino, S Gudipati, AK Hartmann… - Journal of the …, 2017 - ACS Publications
Herein we describe a nucleic acid functionalized nanocapsule in which nucleic acid ligands
are assembled and disassembled in the presence of enzymes. The particles are fully …