Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene arise in 25-30% of all acute myeloid
leukemia (AML) patients. These mutations lead to constitutive activation of the protein …

Mutations in the fms-like tyrosine kinase 3 (FLT3) gene are detected in approximately one-
third of patients with newly diagnosed acute myeloid leukemia (AML). These consist of the …

Introduction: Activating mutations of the FMS-like tyrosine kinase 3 (FLT3) gene occur at
high frequency in acute myeloid leukemia (AML), being detected in> 30% of patients at …

The receptor tyrosine kinase fms-like tyrosine kinase 3 (FLT3), involved in regulating
survival, proliferation, and differentiation of hematopoietic stem/progenitor cells, is …

Introduction The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in one-third of patients
with Acute Myeloid Leukemia (AML). Midostaurin, quizartinib, and gilteritinib have been …

Acute myeloid leukemia (AML) is a highly aggressive illness distinguished by the
accumulation of abnormal hematopoietic precursors in both the bone marrow and peripheral …

Introduction: Mutations of the FLT3 gene are among most common genetic abnormalities
occurring in acute myeloid leukemia (AML) and are associated with dismal prognosis …

Introduction: The FMS-like tyrosine kinase 3 (FLT3) is highly expressed in acute leukemias.
Mutations involving FLT3 are among the most common molecular abnormalities in acute …

The fms-like tyrosine kinase 3 (FLT3) plays an important role in both normal and malignant
hematopoiesis. Activating mutations in the FLT3 receptor can be detected in approximately …

Internal tandem duplications of the FMS-like tyrosine kinase 3 (FLT3) gene are one of the
most frequent gene mutations in acute myeloid leukemia (AML) and are associated with …