Throughout life, bone tissue is in a constant state of turnover. This process of bone
remodeling is the result of a combination of sequential removal of bone tissue by osteoclasts …

Osteopetrosis is the result of mutations affecting osteoclast function. Careful analyses of
osteopetrosis have provided instrumental information on bone remodeling, including the …

Osteopetrosis comprises a group of rare metabolic diseases of skeletal development that
are characterized by a generalized increase in skeletal mass resulting from reduced …

Osteopetrosis is a metabolic bone disease characterized by a systemic increase in skeletal
mass. It results from a defect in the production or function of osteoclasts and is inherited in …

Osteopetrosis describes a heterogeneous group of congenital bone disorders characterized
by a generalized increase in skeletal mass resulting from a primary reduction in osteoclast …

Progress has been made in recent years on the cell biology of the osteoclast and the
pathogenesis of congenital osteopetrosis. New information is critically evaluated and …

Osteopetrosis is a metabolic bone disease inherited in a number of species including
human beings and characterized by a generalized increase in skeletal density detected …

Osteopetrosis is a metabolic bone disease characterized by excessive accumulation of
skeletal mass due to a reduction in bone resorption. The pathogenesis of osteopetrosis is …

The osteopetroses are a heterogeneous group of bone remodeling disorders characterized
by an increase in bone density due to a defect in osteoclastic bone resorption. In humans …

Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a
profound impact on skeletal health. So, disorders of skeletal insufficiency, such as …