[HTML][HTML] Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
Fibroblast heterogeneity has long been recognized in mouse and human lungs,
homeostasis, and disease states. However, there is no common consensus on fibroblast …
homeostasis, and disease states. However, there is no common consensus on fibroblast …
Multiple fibroblast subtypes contribute to matrix deposition in pulmonary fibrosis
Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …
[HTML][HTML] Categorization of lung mesenchymal cells in development and fibrosis
Pulmonary mesenchymal cells are critical players in both the mouse and human during lung
development and disease states. They are increasingly recognized as highly …
development and disease states. They are increasingly recognized as highly …
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis
NJ Lang, J Gote-Schniering… - Science translational …, 2023 - science.org
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing
R Peyser, S MacDonnell, Y Gao, L Cheng… - American journal of …, 2019 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …
The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung …
During lung development, the mesenchyme and epithelium are dependent on each other for
instructive morphogenic cues that direct proliferation, cellular differentiation and …
instructive morphogenic cues that direct proliferation, cellular differentiation and …
[HTML][HTML] Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer
CJ Hanley, S Waise, MJ Ellis, MA Lopez… - Nature …, 2023 - nature.com
Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we
use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry …
use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry …