The transcription factor SOX 2 is essential for the maintenance of embryonic stem cells and
normal development of the esophagus. Our previous study revealed that the SOX2 gene is …

SOX2 is a transcription factor belonging to the SOX gene family, whose activity has been
associated with the maintenance of the stemness and self-renewal of embryonic stem cells …

Purpose: By using cDNA microarray analysis, we identified a transcriptional factor, SOX6,
was frequently downregulated in esophageal squamous cell carcinoma (ESCC). The aim of …

As a transcription factor critical for embryonic and adult stem cell self-renewal and function,
SOX2 gene amplification has been recognized as a driving factor for various cancers …

The transcription factor SOX2 (3q26. 3–q27) is a key regulator of foregut development and
an embryonic stem cell factor cooperating during induction of pluripotency in terminally …

Long noncoding RNAs (lncRNAs) have emerged as new regulators of stem cell pluripotency
and tumorigenesis. The SOX2 gene, a master regulator of pluripotency, is embedded within …

Elevated SOX2 protein levels are closely correlated with the increased incidence of
esophageal squamous cell carcinoma (ESCC). However, establishing effective target …

SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …

Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It
also plays an important role in tissue homeostasis and regeneration, maintaining the …

SOX genes play an important role in a number of developmental processes. SOXs have
been demonstrated to have potential roles as either tumor suppressors or promoters in …