Single cell genomics enables characterization of disease specific cell states, while
improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics …

The correspondence of cell state changes in diseased organs to peripheral protein
signatures is currently unknown. Here, we generated and integrated single‐cell …

Pulmonary fibrosis is a devastating disorder that results in the progressive replacement of
normal lung tissue with fibrotic scar. Available therapies slow disease progression, but most …

The human lung is a relatively quiescent organ in the normal healthy state but contains
stem/progenitor cells that contribute to normal tissue maintenance and either repair or …

In this study, we leveraged a combination of single cell RNAseq, cytometry by time of flight
(CyTOF), and flow cytometry to study the biology of a unique macrophage population in …

Rationale: Little is known about the involvement of T-cells in idiopathic pulmonary fibrosis
(IPF). We employed single-cell RNA sequencing (scRNA-seq) to identify shifts in T-cell …

Fibroblasts, the major extracellular matrix (ECM) producing cells, participate in lung
development, homeostasis, and disease (1). While fibroblast phenotype and function have …

Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …

Editorial summary Single-cell transcriptome profiling has enabled high-resolution analysis of
cellular populations in tissues during development, health, and disease. Recent studies …

Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins
by an activated mesenchyme. Macrophages accumulate in fibrosis, but the role of specific …