A number of immune system components contribute to defense against viral infections.
Although some of these overlap in part with those contributing to resistance against non-viral …

STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and
IL-4, respectively. STAT4 gene knockout (STAT4–/–) mice have markedly reduced Th1 …

To the modern mind, the term 'sepsis' conjures up images of microbes. It is easy to forget that
the word predates any understanding of the microbial origins of infectious disease. Derived …

Hematopoietic stem-cell transplantation is potentially curative treatment for malignant and
non-malignant diseases. The development and severity of graft-versus-host disease (GVHD) …

This is a brief review of 42 cytokines and interleukins that are involved in inflammatory and
immune responses. The cytokines are listed in tables organized as hematopoietic growth …

The gastrointestinal (GI) tract is a major target in graft-versus-host disease (GvHD). In
rodents both tumor necrosis factor (TNF) and Fas-dependent apoptosis have been shown to …

Acute graft-versus-host disease (GVHD) and chronic GVHD remain the major barriers to
successful hematopoietic cell transplantation. The induction of GVHD may be divided into …

Graft-versus-host disease occurs when transplanted donor-derived T lymphocytes recognize
major or minor histocompatibility complex proteins and their associated peptides expressed …

An understanding of the immune system is central to the understanding of how the body
interacts with its surroundings. Presenting an insight into this biological system, this book …

Acute graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow
transplantation (BMT), significantly limits the application of this important therapy. Advances …