Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. During cell cycle
progression from the mid-to late G 1 phase, mammalian cells traverse the restriction point, a …

Cyclin-dependent kinases (CDKs) successively phosphorylate the retinoblastoma protein
(RB) at the restriction point in G1 phase. Hyperphosphorylation results in functional …

The cell cycle regulatory circuit resulting in phosphorylation of the retinoblastoma protein
(pRB) is frequently altered in human cancers. Several mechanisms of disruption are known …

Inactivation of the retinoblastoma (RB) tumor suppressor pathway, via elevated cyclin-
dependent kinase (CDK) activity, is observed in majority of human cancers. Since CDK …

Phosphorylation/inactivation of RB is typically required for cell cycle progression. However,
we have identified a tumor cell line, C33A, which progresses through the cell cycle in the …

The tumor suppressor retinoblastoma protein (RB) plays a central role in cellular growth
regulation, differentiation, and apoptosis. Phosphorylation of RB results in a consequent loss …

The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-
dependent manner and this modification is believed to be important for cells to progress …

The retinoblastoma tumor suppressor protein, RB, contains at least three distinct protein
binding domains. The A/B pocket binds proteins with the LXCXE motif, the C pocket binds …

We propose a new role of retinoblastoma protein as a cell growth activator in its
phosphorylated form. The hyper-phosphorylated retinoblastoma protein generated by the …

Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives
cell proliferation through inhibition of Rb complexes with E2F transcription factors and other …