To direct human embryonic stem (HES) cells to a dopaminergic neuronal fate, we cocultured
HES cells that were exposed to both sonic hedgehog and fibroblast growth factor 8 with …

Human pluripotent stem cells (PSCs) are a promising source of cells for applications in
regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal …

Human embryonic stem (hES) cells are defined by their extensive self-renewal capacity and
their potential to differentiate into any cell type of the human body. The challenge in using …

Human embryonic stem (hES) cells provide a potentially unlimited cell source for
regenerative medicine. Recently, differentiation strategies were developed to direct hES …

Background Human embryonic stem cells (hESCs) may provide an invaluable resource for
regenerative medicine. To move hESCs towards the clinic it is important that cells with …

The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction
in Parkinson's disease, which makes cell replacement a promising therapeutic approach …

We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity
to “rescue” dysfunctional neurons in the brains of aged mice. The study focused on a …

Human embryonic stem (ES) cells en-tered the popular lexicon during the political debate of
summer 2001 and the decision by President George Bush to allow federal funding for …

Embryonic stem (ES) cells are clonal cell lines derived from the inner cell mass of the
developing blastocyst that can proliferate extensively in vitro and are capable of adopting all …

Human embryonic stem (hES) cells have the ability to renew themselves and differentiate
into multiple cell types upon exposure to appropriate signals. In particular, the ability of hES …