SARS-CoV-2 neutralization and protection of hamsters via nasal administration of a humanized neutralizing antibody

M Lebedin, N Petrovsky, K Tabynov, K Tabynov… - bioRxiv, 2024 - biorxiv.org
Monoclonal antibodies are widely used for the treatment of infectious human diseases,
including COVID-19. Since the start of the pandemic, eight monoclonal antibodies against …

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model

M Imbrechts, W Maes, L Ampofo, N Van den Berghe… - Iscience, 2022 - cell.com
Treatment with neutralizing monoclonal antibodies (mAbs) against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) contributes to COVID-19 management …

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

H Qiu, XY Yuan, T Cabral, K Manguiat, A Robinson… - Antiviral Research, 2021 - Elsevier
Vaccination and administration of monoclonal antibody cocktails are effective tools to control
the progression of infectious diseases and to terminate pandemics such as COVID-19 …

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models

M Takeshita, H Fukuyama, K Kamada, T Matsumoto… - bioRxiv, 2022 - biorxiv.org
The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been
highly effective. However, there remain few practical antibodies against viruses that are …

An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies

KE Atanasoff, L Brambilla, DC Adelsberg, S Kowdle… - bioRxiv, 2023 - biorxiv.org
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to over 760 million cases and> …

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

S Halwe, A Kupke, K Vanshylla, F Liberta, H Gruell… - Viruses, 2021 - mdpi.com
Despite the recent availability of vaccines against severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2), there is an urgent need for specific anti-SARS-CoV-2 …

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He… - Science, 2020 - science.org
Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global
health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 …

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

L Li, M Gao, P Jiao, S Zu, Y Deng, D Wan, Y Cao… - Cell & Bioscience, 2022 - Springer
Background Neutralizing antibodies are approved drugs to treat coronavirus disease-2019
(COVID-19) patients, yet mutations in severe acute respiratory syndrome coronavirus (SARS …

Pre-Clinical Development of a Potent Neutralizing Antibody MW3321 With Extensive SARS-CoV-2 Variants Coverage

W Jiang, Z Zhang, Y Zhu, B Chen, C Gu, Z Liu… - Frontiers in …, 2022 - frontiersin.org
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, several variants
of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged and …

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques

RR Cobb, J Nkolola, P Gilchuk, A Chandrashekar… - bioRxiv, 2021 - biorxiv.org
Human monoclonal antibody (mAb) treatments are promising for COVID-19 prevention, post-
exposure prophylaxis, or therapy. However, the titer of neutralizing antibodies required for …