Chromatin conformation links distal target genes to CKD loci

MM Brandt, CA Meddens… - Journal of the …, 2018 - journals.lww.com
Genome-wide association studies (GWASs) have identified many genetic risk factors for
CKD. However, linking common variants to genes that are causal for CKD etiology remains …

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD

N Ledo, YA Ko, ASD Park, HM Kang… - Journal of the …, 2015 - journals.lww.com
Genome-wide association studies (GWASs) have identified multiple loci associated with the
risk of CKD. Almost all risk variants are localized to the noncoding region of the genome; …

Genome-wide association studies of CKD and related traits

A Tin, A Köttgen - Clinical Journal of the American Society of …, 2020 - journals.lww.com
The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Genetic-variation-driven gene-expression changes highlight genes with important functions for kidney disease

YA Ko, H Yi, C Qiu, S Huang, J Park, N Ledo… - The American Journal of …, 2017 - cell.com
Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to
10% of the US population. Genome-wide association studies (GWASs) have identified …

Integrated functional genomic analysis enables annotation of kidney genome-wide association study loci

KB Sieber, A Batorsky, K Siebenthall… - Journal of the …, 2019 - journals.lww.com
Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …

Genetic and epigenetic factors influencing chronic kidney disease

LJ Smyth, S Duffy, AP Maxwell… - American Journal of …, 2014 - journals.physiology.org
Chronic kidney disease (CKD) has become a serious public health problem because of its
associated morbidity, premature mortality, and attendant healthcare costs. The rising …

Integrative biology identifies shared transcriptional networks in CKD

S Martini, V Nair, BJ Keller, F Eichinger… - Journal of the …, 2014 - journals.lww.com
A previous meta-analysis of genome-wide association data by the Cohorts for Heart and
Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci …

Exome-based rare-variant analyses in CKD

S Cameron-Christie, CJ Wolock… - Journal of the …, 2019 - journals.lww.com
Background Studies have identified many common genetic associations that influence renal
function and all-cause CKD, but these explain only a small fraction of variance in these traits …

Genetics of kidney traits in worldwide populations: the Continental Origins and Genetic Epidemiology Network (COGENT) Kidney Consortium

N Franceschini, AP Morris - Kidney international, 2020 - kidney-international.org
We describe our collaborative efforts to increase representation of diverse populations in
genomic research of kidney phenotypes to fill an unmet need to further understanding of the …

A catalog of genetic loci associated with kidney function from analyses of a million individuals

M Wuttke, Y Li, M Li, KB Sieber, MF Feitosa, M Gorski… - Nature …, 2019 - nature.com
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …