In the study of longevity, increasing importance is being placed on the concept of healthy
aging rather than considering the total number of years lived. Although the concept of …

Human longevity is a complex trait in which genetics, epigenetics, environmental and
stochasticity differently contribute. To disentangle the complexity, our studies on genetics of …

The increasing number of older people is resulting in an increased prevalence of age-
related diseases. Research has shown that the ageing process itself is a potential point of …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Over the last century, Western societies experienced a demographic shift driven by
increased lifespan and decreased fertility, resulting in the subversion of the world's …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

The inherent complexity of aging‐related traits can temper progress in unraveling the
genetic origins of healthspan. We focus on two generations in the Framingham Heart Study …

Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …

Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a
strong genetic component appears to have an impact on survival to extreme ages. In order …

The average lifespan of humans is increasing, and with it the percentage of people entering
the 65 and older age group is growing rapidly and will continue to do so in the next 20 years …