Background Depressive episodes and cognitive impairment are major causes of morbidity
and dysfunction in individuals suffering from bipolar disorder (BD). Novel treatment …

Depressive episodes are a major cause of morbidity and dysfunction in individuals suffering
from bipolar disorder. Currently available treatments for this condition have limited efficacy …

Objectives: Creatine plays a pivotal role in brain energy homeostasis, and altered cerebral
energy metabolism may be involved in the pathophysiology of depression. Oral creatine …

Creatine's effects on brain energy metabolism raise the possibility of developing a new
therapeutic strategy in depression focusing on the treatment of metabolic hypoactive brain …

Background: The effects of creatine on brain metabolism and the potential cognitive
enhancing properties of this compound raise the possibility of developing a new …

Objective: Creatine plays a pivotal role in brain energy homeostasis and has been tried in
the treatment of neurologic, neuromuscular, and atherosclerotic disease with a paucity of …

Objective Antidepressants targeting monoaminergic neurotransmitter systems, despite their
immediate effects at the synaptic level, usually require several weeks of administration to …

Objective: Depression among methamphetamine users is more prevalent in females than
males, but gender-specific treatment options for this comorbidity have not been described …

Creatine-containing compounds play an important role in brain energy homeostasis and
may have a beneficial effect on brain functioning. Oral creatine supplementation may …

The potential role of metabolic impairments in the pathophysiology of depression is
motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring …