The gene encoding the p53 tumor suppressor protein is the most frequently mutated
oncogene in cancer patients; yet, generalized strategies for rescuing the function of different …

Soluble proteins with amyloidogenic propensity such as the tumor suppressor protein p53
have high proportion of incompletely desolvated backbone H bonds (HB). Such bonds are …

p53 is a transcription factor that maintains genome integrity, and its function is lost in 50% of
human cancers. The majority of p53 mutations are clustered within the core domain. Here …

At present, p53 is the tumor suppressor protein with the highest known frequency of
mutation. Mutations in p53 will lead to the loss of its anti-cancer function and initiate cancers …

The core domain of the tumour suppressor p53 is of inherently low thermodynamic stability
and also low kinetic stability, which leads to rapid irreversible denaturation. Some oncogenic …

Mutant (Mt) p53 abrogates tumor suppression functions of wild-type (WT) p53 through
mutant-specific, gain-of-function effects, and patients bearing Mt p53 are chemoresistant …

The mutations of R248 to Trp and Gln in the core domain (CD) of the p53 protein are some
of the most common mutations found in human cancer. Although the mutant 248Q and 248W …

The mutation of R273→ H in the p53 core domain (p53-CD) is one of the most common
mutations found in human cancers. Although the 273H p53-CD retains the wild-type …

Abstract p53 is a tumor suppressor protein that maintains genome stability, but its Δ133p53β
and Δ160p53β isoforms promote breast cancer cell invasion. The sequence truncations in …

Lung cancer is a leading fatal malignancy in humans. p53 mutants exhibit not only loss of
tumor suppressor capability but also oncogenic gain-of-function, contributing to lung cancer …