Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies
Genetic factors underlying leukocyte telomere length (LTL) may provide insights into
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …
Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population
The role of low frequency variants associated with telomere length homeostasis in chronic
diseases and mortalities is relatively understudied in the East-Asian population. Here we …
diseases and mortalities is relatively understudied in the East-Asian population. Here we …
Genetic and clinical determinants of telomere length
P Allaire, J He, J Mayer, L Moat… - Human Genetics and …, 2023 - cell.com
Many epidemiologic studies have identified important relationships between leukocyte
telomere length (LTL) with genetics and health. Most of these studies have been significantly …
telomere length (LTL) with genetics and health. Most of these studies have been significantly …
A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related
diseases. We performed genome-wide association studies of mean LTL in 2632 individuals …
diseases. We performed genome-wide association studies of mean LTL in 2632 individuals …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length
C Li, S Stoma, LA Lotta, S Warner, E Albrecht… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …
Genome wide association and linkage analyses identified three loci—4q25, 17q23. 2, and 10q11. 21—associated with variation in leukocyte telomere length: the …
Leukocyte telomere length is believed to measure cellular aging in humans, and short
leukocyte telomere length is associated with increased risks of late onset diseases …
leukocyte telomere length is associated with increased risks of late onset diseases …
Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal
Background Leucocyte telomere length (TL) is a potential biomarker of ageing and risk for
age-related disease. Leucocyte TL is heritable and shows substantial differences by …
age-related disease. Leucocyte TL is heritable and shows substantial differences by …
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross‐sectional and longitudinal analysis
Telomerase is of key importance for telomere maintenance, and variants of the genes
encoding its major subunits, telomerase reverse transcriptase (TERT) and telomerase RNA …
encoding its major subunits, telomerase reverse transcriptase (TERT) and telomerase RNA …
[HTML][HTML] Epigenome-wide association study of leukocyte telomere length
Telomere length is associated with age-related diseases and is highly heritable. It is unclear,
however, to what extent epigenetic modifications are associated with leukocyte telomere …
however, to what extent epigenetic modifications are associated with leukocyte telomere …