Catching active enhancers via H2B N-terminal acetylation
Specific chromatin features, especially histone H3 lysine 27 acetylation, are widely used to
identify active enhancers, yet current methods are imprecise. New work suggests that …
identify active enhancers, yet current methods are imprecise. New work suggests that …
Acetylation of histone H2B marks active enhancers and predicts CBP/p300 target genes
Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
A unique H2B acetylation signature marks active enhancers and predicts their target genes
Chromatin features are widely used for genome-scale mapping of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …
Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters
V Kumar, NA Rayan, M Muratani, S Lim… - Genome …, 2016 - genome.cshlp.org
Although over 35 different histone acetylation marks have been described, the
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
Histone H3 globular domain acetylation identifies a new class of enhancers
Histone acetylation is generally associated with active chromatin, but most studies have
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …
focused on the acetylation of histone tails. Various histone H3 and H4 tail acetylations mark …
Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns
Comparative genomic studies have been useful in identifying transcriptional regulatory
elements in higher eukaryotic genomes, but many important regulatory elements cannot be …
elements in higher eukaryotic genomes, but many important regulatory elements cannot be …
Chromatin signatures of active enhancers
S Spicuglia, L Vanhille - Nucleus, 2012 - Taylor & Francis
Gene-distal cis-regulatory sequences, such as enhancers, are key contributors of tissue-
specific gene expression. In particular, enhancers can be located up to hundreds of …
specific gene expression. In particular, enhancers can be located up to hundreds of …
Causal role of histone acetylations in enhancer function
MM Pradeepa - Transcription, 2017 - Taylor & Francis
Enhancers control development and cellular function by spatiotemporal regulation of gene
expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono …
expression. Co-occurrence of acetylation of histone H3 at lysine 27 (H3K27ac) and mono …
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
H3K27ac is well recognized as a marker for active enhancers and a great indicator of
enhancer activity. However, its functional impact on transcription has not been …
enhancer activity. However, its functional impact on transcription has not been …
A comparison of experimental assays and analytical methods for genome-wide identification of active enhancers
Mounting evidence supports the idea that transcriptional patterns serve as more specific
identifiers of active enhancers than histone marks; however, the optimal strategy to identify …
identifiers of active enhancers than histone marks; however, the optimal strategy to identify …