Muscle atrophy often occurs in cachexia of various inflammation-related diseases. Systemic
inflammation and the inflammatory pathway contribute to cachexia-induced muscle atrophy …

Intramuscular lipid accumulation results in inflammation, which is correlated with impaired
insulin action in the skeletal muscle, an important organ for glucose uptake in the body. In …

Lipid accumulation in skeletal muscle results in dysregulation of protein metabolism and
muscle atrophy. We previously reported that treating C2C12 myotubes with palmitate (PA), a …

Saturated fatty acids like palmitate contribute to muscle atrophy in a number of conditions
(eg, type II diabetes) by altering insulin signaling. Akt is a key modulator of protein balance …

Cachectic muscle wasting is a frequent complication of many inflammatory conditions, due
primarily to excessive muscle catabolism. However, the pathogenesis and intervention …

Skeletal muscle is a major site of insulin action. Intramuscular lipid accumulation results in
inflammation, which has a strong correlation with skeletal muscle insulin resistance (IR). The …

Short-chain fatty acids (SCFA) produced from dietary non-digestible carbohydrate
fermentation have metabolic effects in skeletal muscle; however, their effect on inflammatory …

Inflammation is a major cause of skeletal muscle atrophy in various diseases. 2-Hydroxy-4′-
methoxychalcone (AN07) is a chalcone-based peroxisome-proliferator-activated receptor …

Background & aims Muscle atrophy is a public health issue and inflammation is a major
cause of muscle atrophy. While docosahexaenoic acid (DHA) and eicosapentaenoic acid …

The chain length of saturated fatty acids may dictate their impact on inflammation and
mitochondrial dysfunction, two pivotal players in the pathogenesis of insulin resistance …