Overexpression of the severe acute respiratory syndrome coronavirus-2 receptor, angiotensin-converting enzyme 2, in diabetic kidney disease: implications for kidney …

RE Gilbert, L Caldwell, PS Misra, K Chan… - Canadian Journal of …, 2021 - Elsevier
Objectives Diabetes is associated with adverse outcomes, including death, after coronavirus
disease 19 (COVID-19) infection. Beyond the lungs, Severe Acute Respiratory Syndrome …

[HTML][HTML] Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease

S Tsukamoto, H Wakui, K Azushima, T Yamaji… - Scientific Reports, 2021 - nature.com
Elevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential
targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of …

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

X Jiang, JM Eales, D Scannali… - European heart …, 2020 - academic.oup.com
Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute
respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 …

Coronavirus disease 2019 and hypertension: the role of angiotensin-converting enzyme 2 and the renin-angiotensin system

DL Edmonston, AM South, MA Sparks… - Advances in chronic …, 2020 - Elsevier
Hypertension emerged from early reports as a potential risk factor for worse outcomes for
persons with coronavirus disease 2019 (COVID-19). Among the putative links between …

Angiotensin‐converting enzyme 2 and transmembrane protease serine 2 in female and male patients with end‐stage kidney disease

S Arefin, L Hernandez, LJ Ward… - European Journal of …, 2022 - Wiley Online Library
Background Individuals with chronic kidney disease are affected by acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) due to multiple comorbidities and altered immune …

[HTML][HTML] SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease

R Menon, EA Otto, R Sealfon, V Nair, AK Wong… - Kidney international, 2020 - Elsevier
COVID-19 morbidity and mortality are increased in patients with diabetes and kidney
disease via unknown mechanisms. SARS-CoV-2 uses angiotensin-converting enzyme 2 …

On the essentiality of the angiotensin converting enzyme 2 receptor for SARS‐CoV‐2 infection and the potential of soluble angiotensin converting enzyme 2 proteins …

L Hassler, J Penninger, D Batlle - Clinical and Translational …, 2022 - Wiley Online Library
After the outbreak of severe actute respiratory syndrom coronavirus (SARS-CoV) in 2003, it
was shown that angiotensin converting enzyme 2 (ACE2) was the receptor for this …

Renin–angiotensin system blockade in the COVID-19 pandemic

JB Cohen, AM South, HA Shaltout… - Clinical Kidney …, 2021 - academic.oup.com
In the early months of the coronavirus disease 2019 (COVID-19) pandemic, a hypothesis
emerged suggesting that pharmacologic inhibitors of the renin–angiotensin system (RAS) …

Lung and kidney ACE2 and TMPRSS2 in renin-angiotensin system blocker–treated comorbid diabetic mice mimicking host factors that have been linked to severe …

SN Batchu, H Kaur, VG Yerra, SL Advani, MG Kabir… - Diabetes, 2021 - Am Diabetes Assoc
The causes of the increased risk of severe coronavirus disease 2019 (COVID-19) in people
with diabetes are unclear. It has been speculated that renin-angiotensin system (RAS) …

[HTML][HTML] COVID-19 and the renin-angiotensin system

L Malha, FB Mueller, MS Pecker, SJ Mann… - Kidney international …, 2020 - kireports.org
In late 2019, a coronavirus disease (COVID-19) leading to severe acute respiratory
syndrome (SARS) started in China and has become a pandemic. The responsible virus has …