Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization

D Lapuente, J Fuchs, J Willar, A Vieira Antão… - Nature …, 2021 - nature.com
Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are
needed to maintain or increase immunity due to waning responses and the emergence of …

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

J Tang, C Zeng, TM Cox, C Li, YM Son, IS Cheon… - Science …, 2022 - science.org
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the
circulation; however, it is currently unknown whether it elicits effective immune responses in …

Intranasal delivery of MVA vector vaccine induces effective pulmonary immunity against SARS-CoV-2 in rodents

B Bošnjak, I Odak, J Barros-Martins, I Sandrock… - Frontiers in …, 2021 - frontiersin.org
Antigen-specific tissue-resident memory T cells (Trms) and neutralizing IgA antibodies
provide the most effective protection of the lungs from viral infections. To induce those …

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

S Afkhami, MR D'Agostino, A Zhang, HD Stacey… - Cell, 2022 - cell.com
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

H Lei, A Alu, J Yang, W Ren, C He, T Lan… - … and Targeted Therapy, 2022 - nature.com
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global
health and economy. Several effective vaccines are available now, but additional booster …

[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …

[HTML][HTML] Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques

Y Sui, J Li, R Zhang, SK Prabhu, H Andersen… - JCI insight, 2021 - ncbi.nlm.nih.gov
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have
focused on systemic immunization, here we compared the protective efficacy of 2 …

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

SN Langel, S Johnson, CI Martinez… - Science Translational …, 2022 - science.org
Transmission-blocking strategies that slow the spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and protect against coronavirus disease 2019 (COVID-19) are …

A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice

N Tokunoh, S Tamiya, M Watanabe… - Frontiers in …, 2023 - frontiersin.org
Introduction Vaccinations are ideal for reducing the severity of clinical manifestations and
secondary complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

K McMahan, F Wegmann, M Aid, M Sciacca, J Liu… - Nature, 2024 - nature.com
A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against
infection with current Omicron subvariants,, although they still provide protection against …