Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but
increasing resistance has encouraged the development of new therapeutic agents against …

Dihydropteroate synthase (DHPS) is the validated drug target for sulfonamide antimicrobial
therapy. However, due to widespread drug resistance and poor tolerance, the use of …

Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the
target of the sulfonamide class of antibacterials. Resistance and toxicities associated with …

Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered.
The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to …

Background The enzyme dihydropteroate synthase (DHPS) participates in the de novo
synthesis of folate cofactors by catalyzing the formation of 7, 8-dihydropteroate from …

DHPS (dihydropteroate synthase) catalyses an essential step in the biosynthesis of folic acid
and is the target for the sulfonamide group of antimicrobial drugs. In the present paper we …

The declining effectiveness of current antibiotics due to the emergence of resistant bacterial
strains dictates a pressing need for novel classes of antimicrobial therapies, preferably …

The enzyme 6-hydroxymethyl-7, 8-dihydropteroate synthase (DHPS) catalyzes the
condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin …

Dihydropteroate synthase (DHPS) is an enzyme of the folate biosynthesis pathway, which
catalyzes the formation of 7, 8‐dihydropteroate (DHPt) from 6‐hydroxymethyl‐7, 8 …

The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the
folate pathway of bacteria and primitive eukaryotes. However, resistance mutations have …