Exon architecture controls mRNA m6A suppression and gene expression
N 6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
and plays crucial roles in diverse physiological processes. Using a massively parallel assay …
[HTML][HTML] Exon junction complex shapes the m6A epitranscriptome
Abstract N6-methyladenosine (m6A), the most abundant modification of mRNA, is essential
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
for normal development and dysregulation promotes cancer. m6A is highly enriched in the …
[HTML][HTML] Exon-intron boundary inhibits m6A deposition, enabling m6A distribution hallmark, longer mRNA half-life and flexible protein coding
Z Luo, Q Ma, S Sun, N Li, H Wang, Z Ying… - Nature …, 2023 - nature.com
Regional bias of N 6-methyladenosine (m6A) mRNA modification avoiding splice site
region, calls for an open hypothesis whether exon-intron boundary could affect m6A …
region, calls for an open hypothesis whether exon-intron boundary could affect m6A …
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
D Dominissini, S Moshitch-Moshkovitz, S Schwartz… - Nature, 2012 - nature.com
An extensive repertoire of modifications is known to underlie the versatile coding, structural
and catalytic functions of RNA, but it remains largely uncharted territory. Although …
and catalytic functions of RNA, but it remains largely uncharted territory. Although …
The RNA N6-methyladenosine modification landscape of human fetal tissues
S Xiao, S Cao, Q Huang, L Xia, M Deng, M Yang… - Nature cell …, 2019 - nature.com
A single genome gives rise to diverse tissues through complex epigenomic mechanisms,
including N 6-methyladenosine (m6A), a widespread RNA modification that is implicated in …
including N 6-methyladenosine (m6A), a widespread RNA modification that is implicated in …
[HTML][HTML] A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
B Liu, DK Merriman, SH Choi, MA Schumacher… - Nature …, 2018 - nature.com
Abstract N 6-Methyladenosine (m6A) is an abundant post-transcriptional RNA modification
that influences multiple aspects of gene expression. In addition to recruiting proteins, m6A …
that influences multiple aspects of gene expression. In addition to recruiting proteins, m6A …
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
DNA and histone modifications have notable effects on gene expression. Being the most
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …
prevalent internal modification in mRNA, the N 6-methyladenosine (m6A) mRNA …
[HTML][HTML] Exclusion of m6A from splice-site proximal regions by the exon junction complex dictates m6A topologies and mRNA stability
Summary N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
uniformly distributed across the transcriptome, yet the basis for its selective deposition is …
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N 6-methyladenosine (m6A) modification have been limited
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such …
m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome
Abstract N 6-Methyladenosine (m6A) is a widespread, reversible chemical modification of
RNA molecules, implicated in many aspects of RNA metabolism. Little quantitative …
RNA molecules, implicated in many aspects of RNA metabolism. Little quantitative …