Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …

Development of the metanephric kidney is strongly dependent on complex signaling
pathways and cell–cell communication between at least four major progenitor cell …

The functional unit of the kidney is the nephron. During its organogenesis, the mammalian
metanephric kidney generates thousands of nephrons over a protracted period of fetal life …

Nephron formation continues throughout kidney morphogenesis in both mice and humans.
Lineage tracing studies in mice identified a self‐renewing Six2‐expressing nephron …

Mammalian nephrons arise from a limited nephron progenitor pool through a reiterative
inductive process extending over days (mouse) or weeks (human) of kidney development …

Cellular interactions among nephron, interstitial, and collecting duct progenitors drive
mammalian kidney development. In mice, Six2+ nephron progenitor cells (NPCs) and …

The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …

The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …