Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

Stem cells undergo extensive self-renewal and have the capacity to differentiate along
multiple cell lineages. Progression from stem cells into differentiated progeny requires long …

Despite its clinical and fundamental importance, our understanding of early human
development remains limited. Stem cell-derived, embryo-like structures (or embryoids) …

Fundamental questions in developmental biology are: what genes are expressed, where
and when they are expressed, what is the level of expression and how are these programs …

Attainment of the differentiated state during the final stages of somatic cell differentiation is
closely tied to cell cycle progression. Much less is known about the role of the cell cycle at …

A major challenge in biology is to understand how genetic information is interpreted to direct
the formation of specialized tissues within a multicellular organism. During differentiation …

Pathways underlying mouse embryonic development have always informed efforts to derive,
maintain, and drive differentiation of human pluripotent stem cells. However, direct …

Two critical properties of stem cells are self-renewal and multipotency. The maintenance of
their “stemness” state and commitment to differentiation are therefore tightly controlled by …

The preimplantation period of mouse early embryonic development is devoted to the
specification of two extraembryonic tissues and their spatial segregation from the pluripotent …