Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …

Although advances in single-cell technologies have enabled the characterization of multiple
omics profiles in individual cells, extracting functional and mechanistic insights from such …

Elucidating the mechanisms of complex diseases such as cardiovascular disease (CVD)
remains a significant challenge due to multidimensional alterations at molecular, cellular …

With the development of ever more powerful and versatile high-throughput sequencing
techniques and innovative ways to capture single cells, mapping the multicellular tissues at …

Computational tools for integrative analyses of diverse single-cell experiments are facing
formidable new challenges including dramatic increases in data scale, sample …

Single cell analyses encompass multiple approaches that, we suggest, can be summarized
by two unifying goals: to explain the cellular composition of tissues; and to characterize the …

Genome-wide association studies (GWAS) provide a powerful means to identify loci and
genes contributing to disease, but in many cases the related cell types/states through which …

Despite the emergence of experimental methods for simultaneous measurement of multiple
omics modalities in single cells, most single-cell datasets include only one modality. A major …

Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …

Autoimmune diseases are a major cause of mortality,. Current treatments often yield severe
insult to host tissue. It is hypothesized that improved “precision medicine” therapies will …