Background In spite of its invasive nature and risks, kidney biopsy is currently required for
precise diagnosis of many chronic kidney diseases (CKDs). Here, we explored the …

Background The contrast between a high prevalence of chronic kidney disease (CKD) and
the low incidence of end-stage renal disease highlights the need for new biomarkers of …

Diabetic nephropathy (DN) is a progressive kidney disease, a well-known complication of
long-standing diabetes. DN is the most frequent reason for dialysis in many Western …

In this article, the benefits of urinary proteomics in comparison with kidney biopsy are
discussed. The majority of urinary proteins are generated by the kidney, hence the urinary …

Background Type 2 diabetic kidney disease is the most common cause of chronic kidney
diseases (CKD) and end-stage renal diseases (ESRD). Although kidney biopsy is …

Background and hypothesis Specific urinary peptides hold information on disease
pathophysiology, which, in combination with artificial intelligence, could enable non-invasive …

Non-invasive urinary peptide biomarkers are able to detect and predict chronic kidney
disease (CKD). Moreover, specific urinary peptides enable discrimination of different CKD …

Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still
challenges in clinical nephrology. Definition of biomarkers on the basis of proteome …

Background We investigate whether the urinary proteome refines the diagnosis of renal
dysfunction, which affects over 10% of the adult population. Methods We measured serum …

Results After multivariable adjustment and correction for multiple testing, 46 different
proteins were associated with histopathologic lesions. The top-performing markers positively …