Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …

This special issue, entitled “the role of arginase in endothelial dysfunction,” assembles
original contributions (1–4), as well as timely reviews (5–12) broadly related to the …

Oxidative stress and inflammation in the vascular wall are essential mechanisms of
atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

The endothelial production of nitric oxide (NO) mediates endothelium-dependent
vasorelaxation and restrains vascular inflammation, smooth muscle cell proliferation, and …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

As arginine can serve as precursor to a wide range of compounds, including nitric oxide,
creatine, urea, polyamines, proline, glutamate and agmatine, there is considerable interest …

Endothelial dysfunction and resulting vascular pathology have been identified as an early
hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …