Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

The accumulation of 'senescent'cells has long been proposed to act as an ageing
mechanism. These cells display a radically altered transcriptome and degenerative …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells
remain metabolically active and often acquire a distinctive bioactive secretory phenotype …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

Reliable ways to identify senescent cells represent a bottleneck for understanding the roles
of senescence in physiology and disease. This Comment examines the challenges of …

As the world's population progressively ages, the burden on the socio-economic and health
systems is escalating, demanding sustainable and lasting solutions. Cellular senescence …

The contribution of cellular senescence to a diverse range of biological processes, including
normal physiology, ageing, and pathology were long overlooked but have now taken centre …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …