In many biological processes, increasing the rate of transport of a limiting nutrient can
enhance the rate of product formation. In aerobic fermentation systems, the rate of oxygen …

Mixing in bioreactors is known to be crucial for achieving efficient mass and heat transfer,
both of which thereby impact not only growth of cells but also product quality. In a typical …

The biomanufacturing processes that produce biologic drugs has become an extremely
important area of study within the pharmaceutical industry. Within such processes, the drug …

The growing global population and heightened concern for climate change leads to
increased interest in utilizing microbial fermentations to replace polluting production …

Industrial aerobic fermentation processes are performed in large-scale bioreactors (> 20 m
3). Understanding the local values of the velocity field, the eddy dissipation rate and the gas …

In the present paper, gas dispersion in a laboratory scale (5L) stirred bioreactor is modelled
using a commercial computational fluid dynamics (CFD) code FLUENT 6.2 (Fluent Inc …

Oxygen supply in aerobic bioprocesses is of crucial importance. For this reason, this paper
presents the oxygen demand of different cells and summarizes experimental and numerical …

Since their introduction in 2001 miniaturized bioreactor systems have made great advances
in function and performance. In this article the dissolved oxygen (DO) transfer performance …

A mechanistic in-silico approach for predicting mixing and mass transfer in a two-phase
stirred tank bioreactor is presented. This fully transient approach, which is tailored to run on …

CFD (computational fluid dynamics) has been used to model upstream bioprocessing steps
such as fermentation and homogenization. The focus of these studies has oftentimes been …