Absorption of UV rays by DNA generates the formation of mutagenic cyclobutane pyrimidine
dimers (CPD) and pyrimidine (6–4) pyrimidone photoproducts (6-4PP). These damages are …

Sunlight exposure of the eye leads to pathologies including photokeratitis, cortical cataracts,
pterygium, actinic conjunctivitis and age‐related macular degeneration. It is well established …

Simple Summary The sun is a deadly laser, and its damaging rays harm exposed tissues
such as our skin and eyes. The skin's protection and repair mechanisms are well understood …

Exposition to ultraviolet (UV) light is involved in the initiation and the progression of skin
cancer. The genotoxicity of UV light is mainly attributed to the induction of cyclobutane …

UV-damaged DNA-binding protein (UV-DDB) is essential for global genome repair (GGR) of
UV-induced cyclobutane pyrimidine dimers (CPD). Unlike human cells, rodent epidermal …

Simple Summary Ultraviolet light from the sun causes DNA damage and is a major
exogenous genotoxin, particularly affecting the skin and eyes of humans. UV-induced …

It is well known that UV exposure of human skin induces DNA damage, and the cumulative
effect of such repeated damage is an important contributor to the development of skin …

Cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-
4PPs) are the two main classes of mutagenic DNA damages induced by UVB radiation …

Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is
a lengthy process (t 1/2> 48 h). Using the T4 endonuclease V-modified comet assay, we …

UV-damaged DNA-binding protein (UV-DDB) is essential for global genome nucleotide
excision repair of UV-induced cyclobutane pyrimidine dimers (CPD) and accelerates repair …