Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …

Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and
heterogeneous disease with multiple contributors to its pathophysiology, including vascular …

Background: Cerebrovascular disease is a common comorbidity in patients with Alzheimer's
disease (AD). It is believed to contribute additively to the cognitive impairment and to lower …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …

In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …